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Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal.

Abstract:

Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of control measures. If the goal of elimination is to be achieved, additional control measures including an effective and durable vaccine will be required. Studies utilising the prime-boost approach to deliver viral vectors encoding the pre-erythrocytic antigen ME-TRAP (multiple epitope thrombospondin-related adhesion protein) have shown promising safety, immunogenicity and efficacy in sporozoite challeng...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0167951

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Grant:
Malaria Vectored Vaccines Consortium (MVVC) IP.2008.31100.001
Medical Research Council More from this funder
Swedish International Development Cooperation Agency More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
12
Chapter number:
e0167951
Publication date:
2016-12-15
Acceptance date:
2016-11-22
DOI:
ISSN:
1932-6203
Pubs id:
pubs:666493
URN:
uri:ed7ea19f-4bb5-4e90-8d78-139c154c3d2f
UUID:
uuid:ed7ea19f-4bb5-4e90-8d78-139c154c3d2f
Local pid:
pubs:666493
Paper number:
12

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