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Prediction of acute myeloid leukaemia risk in healthy individuals

Abstract:

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure1. The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion2,3. However, recurrent AML mutations also ac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41586-018-0317-6

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
559
Issue:
7714
Pages:
400-404
Publication date:
2018-07-09
Acceptance date:
2018-05-03
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:869196
URN:
uri:ed58b691-a800-47eb-b30c-23ee96075b4e
UUID:
uuid:ed58b691-a800-47eb-b30c-23ee96075b4e
Local pid:
pubs:869196
Language:
English

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