Journal article
Evaluation of the efficacy of chad63-mva vectored vaccines expressing circumsporozoite protein and me-trap against controlled human malaria infection in malaria-naive individuals
- Abstract:
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Background: Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer of T-cells in humans, demonstrating significant efficacy when expressing the preerythrocytic antigen insert multiple epitope–thrombospondin-related adhesion protein (ME-TRAP). We hypothesized tha...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 741.7KB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiu579
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Funding
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Journal of Infectious Diseases More from this journal
- Volume:
- 211
- Issue:
- 7
- Pages:
- 1076-1086
- Publication date:
- 2014-10-21
- Acceptance date:
- 2014-10-10
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pmid:
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25336730
Item Description
Terms of use
- Copyright holder:
- Hodgson et al
- Copyright date:
- 2014
- Notes:
- © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America. This is an Open Accessarticle distributed undertheterms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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