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Journal article

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Abstract:

Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC.We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 control...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/bjc.2016.188

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Oxford Comprehensive Biomedical Research Centre More from this funder
Publisher:
Cancer Research UK Publisher's website
Journal:
British journal of cancer Journal website
Publication date:
2016-06-23
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:ed28df96-8d37-4531-a38f-830e66f5da6d
Source identifiers:
630903
Local pid:
pubs:630903

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