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Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care

Abstract:

OBJECTIVE:To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin. DESIGN:Prospective open cohort study. SETTING:UK general practices contributing to QResearch or Clinical Practice Research Datalink. PARTICIPANTS:132 231 warfarin, 7744 dabigatran, 37 863 rivaroxaban, and 18 223 apixaban users without anticoagulant prescriptions for 12 months before study entry, su...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/bmj.k2505

Authors


Vinogradova, Y More by this author
Coupland, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Oxford college:
St Annes College
ORCID:
0000-0002-2479-7283
Publisher:
British Medical Journal Publishing Group Publisher's website
Journal:
British Medical Journal Journal website
Volume:
362
Issue:
k2505
Publication date:
2018-07-04
Acceptance date:
2018-05-22
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
Pubs id:
pubs:972851
URN:
uri:ecdbe3ef-5ffd-42fb-98f7-5db602346a32
UUID:
uuid:ecdbe3ef-5ffd-42fb-98f7-5db602346a32
Local pid:
pubs:972851
Language:
English

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