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Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package

Abstract:
There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
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Department:
Structural Genomics Consortium
Role:
Principal Investigator, Creator

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Department:
Structural Genomics Consortium
Role:
Researcher
Department:
Structural Genomics Consortium
Role:
Researcher
Department:
Structural Genomics Consortium
Role:
Researcher
Department:
Structural Genomics Consortium
Role:
Researcher
Role:
Researcher
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Publisher:
University of Oxford
Publication date:
2018
DOI:

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