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The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions.

Abstract:

The biological consequences of clusters containing a single strand break and base lesion(s) remain largely unknown. In the present study we determined the mutagenicities of two- and three-lesion clustered damage sites containing a 1-nucleotide gap (GAP) and 8-oxo-7,8-dihydroguanine(s) (8-oxoG(s)) in Escherichia coli. The mutation frequencies (MFs) of bi-stranded two-lesion clusters (GAP/8-oxoG), especially in mutY-deficient strains, were high and were similar to those for bi-stranded clusters...

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Publication status:
Published

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Authors


Noguchi, M More by this author
Urushibara, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Shikazono, N More by this author
Journal:
Mutation research
Volume:
732
Issue:
1-2
Pages:
34-42
Publication date:
2012-04-05
DOI:
EISSN:
1873-135X
ISSN:
0027-5107
URN:
uuid:ec371942-8fb2-468a-898a-56229205adbf
Source identifiers:
245832
Local pid:
pubs:245832

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