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Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia.

Abstract:

RATIONALE: Notch signaling regulates vascular development. However, the implication of the Notch ligand Delta-like 4 (Dll4) in postischemic angiogenesis remains unclear. OBJECTIVE: We investigated the role of Dll4/Notch signaling in reparative angiogenesis using a mouse model of ischemia. METHODS AND RESULTS: We found Dll4 weakly expressed in microvascular endothelial cells of normoperfused muscles. Conversely, Dll4 is upregulated following ischemia and localized at the forefront of sproutin...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
Journal:
Circulation research
Volume:
107
Issue:
2
Pages:
283-293
Publication date:
2010-07-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
266830

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