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Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells

Abstract:

O’nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection models, we demonstrated that a preexisting blood-stage Plasmodium infection suppresses ONNV-induced pathologies. We further showed that suppression of viremia and virus dissemination are dep...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.26508/lsa.202101272

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Role:
Author
ORCID:
0000-0001-6939-8123
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Role:
Author
ORCID:
0000-0002-8294-1474
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Name:
Health and Biomedical Sciences (HBMS) Open Fund Shared Infrastructure Support
Publisher:
Life Science Alliance
Journal:
Life Science Alliance More from this journal
Volume:
5
Issue:
4
Article number:
e202101272
Publication date:
2022-01-17
Acceptance date:
2022-01-04
DOI:
EISSN:
2575-1077
Pmid:
35039441
Language:
English
Keywords:
Pubs id:
1235886
Local pid:
pubs:1235886
Deposit date:
2023-01-09

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