- Abstract:
-
Background: Paracetamol is a well-tolerated antipyretic widely used in severe malaria management. The study aimed to develop and validate a rapid liquid chromatography mass spectrometry (LC-MS/MS) assay to quantify paracetamol in plasma from patients with severe malaria. Results: Plasma samples were extracted with organic solvent and assayed in less than 5.5 minutes. The assay response was linear (0.125-50 mg/L) with total intra- and inter-assay imprecision ... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 594.7KB)
-
- Publisher copy:
- 10.4155/fsoa-2018-0039
-
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- Publisher:
- Future Science Publisher's website
- Journal:
- Future Science OA Journal website
- Volume:
- 4
- Issue:
- 8
- Publication date:
- 2018-08-15
- Acceptance date:
- 2018-06-25
- DOI:
- ISSN:
-
2056-5623
- Pubs id:
-
pubs:865217
- URN:
-
uri:ebe4fffc-2ad2-47f4-bde7-d4cec214d5f1
- UUID:
-
uuid:ebe4fffc-2ad2-47f4-bde7-d4cec214d5f1
- Local pid:
- pubs:865217
- Copyright holder:
- Kin-Ting Kam et al.
- Copyright date:
- 2018
- Notes:
- © 2018 Kin Ting Richard Kam. This work is licensed under the Creative Commons Attribution 4.0 License.
Journal article
Quantitation of paracetamol by liquid chromatography-mass spectrometry in human plasma in support of clinical trial
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