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Journal article

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Abstract:

Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P. falciparum female gametocyte activation assay (Pf FGAA), which assesses stage V female gametocyte viability and functionality using Pfs25 expression. We identify over 400 compounds with activities <2μM, chemically classified into 57 clusters ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15160

Authors


Miguel-Blanco, C More by this author
Bardera, AI More by this author
de Las Heras, L More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
15160
Publication date:
2017-03-03
Acceptance date:
2017-05-17
DOI:
ISSN:
2041-1723
Pubs id:
pubs:696729
URN:
uri:ebc33149-ebf8-4484-813e-d2649947ce90
UUID:
uuid:ebc33149-ebf8-4484-813e-d2649947ce90
Local pid:
pubs:696729

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