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Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer

Abstract:

The addition of hypoxia modifiers carbogen and nicotinamide (CON) to radiotherapy (RT) improved overall survival (OS) in bladder cancer patients in the BCON phase III clinical trial. We investigate whether expression of hsa-miR-210 in BCON patient samples reflects hypoxia and predicts benefit from hypoxia modification.In all, 183 T1-T4a bladder cancer samples were available for miR-210 analysis. A total of 86 received RT+CON and 97 received RT alone. TaqMan qPCR plates were used to assess miR...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/bjc.2016.218

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Department:
St Hughs College
Role:
Author
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Publisher:
Cancer Research UK Publisher's website
Journal:
British journal of cancer Journal website
Volume:
115
Issue:
5
Pages:
571-578
Publication date:
2016-07-21
Acceptance date:
2016-06-15
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pubs id:
pubs:635003
URN:
uri:ead72bdb-f1c9-458a-b78f-f073c375676b
UUID:
uuid:ead72bdb-f1c9-458a-b78f-f073c375676b
Local pid:
pubs:635003

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