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Journal article

Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors

Abstract:
Objective: Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences. Method: We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary out... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1176/appi.ajp.2017.16121358

Authors


Chaimani, A More by this author
Mavridis, D More by this author
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Publisher:
American Psychiatric Publishing Publisher's website
Journal:
American Journal of Psychiatry Journal website
Volume:
174
Issue:
10
Pages:
927-942
Publication date:
2017-05-25
Acceptance date:
2017-03-16
DOI:
EISSN:
1535-7228
ISSN:
0002-953X
Pubs id:
pubs:686267
URN:
uri:ea6ced45-9327-41b8-96dd-e9de1d8cde04
UUID:
uuid:ea6ced45-9327-41b8-96dd-e9de1d8cde04
Local pid:
pubs:686267
Paper number:
10

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