- Abstract:
-
Objective: Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences. Method: We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary out... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pptx, 85.5kb)
-
(pptx, 114.2kb)
-
(pptx, 112.0kb)
-
(pdf, 229.1kb)
-
(pptx, 73.6kb)
-
- Publisher copy:
- 10.1176/appi.ajp.2017.16121358
- Funding agency for:
- Cipriani, A
- Publisher:
- American Psychiatric Publishing Publisher's website
- Journal:
- American Journal of Psychiatry Journal website
- Volume:
- 174
- Issue:
- 10
- Pages:
- 927-942
- Publication date:
- 2017-05-25
- Acceptance date:
- 2017-03-16
- DOI:
- EISSN:
-
1535-7228
- ISSN:
-
0002-953X
- Pubs id:
-
pubs:686267
- URN:
-
uri:ea6ced45-9327-41b8-96dd-e9de1d8cde04
- UUID:
-
uuid:ea6ced45-9327-41b8-96dd-e9de1d8cde04
- Local pid:
- pubs:686267
- Paper number:
- 10
- Copyright holder:
- American Psychiatric Association
- Copyright date:
- 2017
- Notes:
-
Copyright © American Psychiatric Association. This is the accepted manuscript version of the article. The final version is available online from American Psychiatric Association at: https://doi.org/10.1176/appi.ajp.2017.16121358
Journal article
Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors
Actions
Access Document
Authors
Funding
+ National Institute for Health Research Oxford Cognitive Health Clinical Research Facility
More from this funder
Bibliographic Details
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record