- Abstract:
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Objective: Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences. Method: We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary out... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
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(pptx, 85.5kb)
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(pptx, 114.2kb)
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(pptx, 112.0kb)
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(pdf, 229.1kb)
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(pptx, 73.6kb)
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- Publisher copy:
- 10.1176/appi.ajp.2017.16121358
-
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- Funding agency for:
- Cipriani, A
- Publisher:
- American Psychiatric Publishing Publisher's website
- Journal:
- American Journal of Psychiatry Journal website
- Volume:
- 174
- Issue:
- 10
- Pages:
- 927-942
- Publication date:
- 2017-05-25
- Acceptance date:
- 2017-03-16
- DOI:
- EISSN:
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1535-7228
- ISSN:
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0002-953X
- Pubs id:
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pubs:686267
- URN:
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uri:ea6ced45-9327-41b8-96dd-e9de1d8cde04
- UUID:
-
uuid:ea6ced45-9327-41b8-96dd-e9de1d8cde04
- Local pid:
- pubs:686267
- Paper number:
- 10
- Copyright holder:
- American Psychiatric Association
- Copyright date:
- 2017
- Notes:
-
Copyright © American Psychiatric Association. This is the accepted manuscript version of the article. The final version is available online from American Psychiatric Association at: https://doi.org/10.1176/appi.ajp.2017.16121358
Journal article
Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors
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