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The early antibody-dependent cell-mediated cytotoxicity response is associated with lower viral set point in individuals with primary HIV infection

Abstract:

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections. However, the role of ADCC in response to primary HIV infection is poorly understood. In the present study, we explored the ADCC response and evaluated its characteristics in 85 HIV-infected individuals, including 42 with primary infections. Our results showed that ADCC occurs during acute infection, and the ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.02322

Authors


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Mega-Projects of National Science Research for the 12th Five-Year Plan More from this funder
Mega-Projects of National Science Research for the 13th Five-Year Plan More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
OCT
Pages:
2322
Publication date:
2018-10-09
Acceptance date:
2018-09-18
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Pubs id:
pubs:931203
URN:
uri:ea510d3c-21ff-4033-a032-eb082c3b5d61
UUID:
uuid:ea510d3c-21ff-4033-a032-eb082c3b5d61
Local pid:
pubs:931203

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