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Principles of reconstructing the subclonal architecture of cancers

Abstract:

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor's subclonal composition through the identification of populations of cells with shared mutations. We describe the principles that underlie subclonal reconstruction through single nucleotide variants (SNVs) or copy ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1101/cshperspect.a026625

Authors


Dentro, SC More by this author
More by this author
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Van Loo, P More by this author
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Cold Spring Harbor Perspectives in Medicine Journal website
Volume:
7
Issue:
8
Pages:
Article: a026625
Publication date:
2017-03-07
DOI:
ISSN:
2157-1422
Pubs id:
pubs:693590
URN:
uri:ea40d5b1-a4f8-447e-9e5a-4c09ae9a0e2a
UUID:
uuid:ea40d5b1-a4f8-447e-9e5a-4c09ae9a0e2a
Local pid:
pubs:693590
Language:
English

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