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Vortioxetine reduces BOLD signal during performance of the N-Back working memory task: a randomised neuroimaging trial in remitted depressed patients and healthy controls

Abstract:

Cognitive dysfunction is common in depression during both acute episodes and remission. Vortioxetine is a novel multi-modal antidepressant that has improved cognitive function including executive function in depressed patients in randomised placebo controlled clinical trials. However, it is unclear whether vortioxetine is able to target directly the neural circuitry implicated in the cognitive deficits in depression. Remitted depressed (n=48) and healthy volunteers (n=48) were randomised to r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/mp.2017.104

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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Department:
Oxford, MSD, Psychiatry
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Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Molecular Psychiatry Journal website
Volume:
23
Pages:
1127–1133
Publication date:
2017-05-25
Acceptance date:
2017-02-02
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pubs id:
pubs:675630
URN:
uri:e9fc8bfb-51c2-45ed-9982-5447d0fc09bd
UUID:
uuid:e9fc8bfb-51c2-45ed-9982-5447d0fc09bd
Local pid:
pubs:675630

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