- Abstract:
-
Cognitive dysfunction is common in depression during both acute episodes and remission. Vortioxetine is a novel multi-modal antidepressant that has improved cognitive function including executive function in depressed patients in randomised placebo controlled clinical trials. However, it is unclear whether vortioxetine is able to target directly the neural circuitry implicated in the cognitive deficits in depression. Remitted depressed (n=48) and healthy volunteers (n=48) were randomised to r...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 247.1KB)
-
- Publisher copy:
- 10.1038/mp.2017.104
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Molecular Psychiatry Journal website
- Volume:
- 23
- Pages:
- 1127–1133
- Publication date:
- 2017-05-25
- Acceptance date:
- 2017-02-02
- DOI:
- EISSN:
-
1476-5578
- ISSN:
-
1359-4184
- Pubs id:
-
pubs:675630
- URN:
-
uri:e9fc8bfb-51c2-45ed-9982-5447d0fc09bd
- UUID:
-
uuid:e9fc8bfb-51c2-45ed-9982-5447d0fc09bd
- Local pid:
- pubs:675630
- Copyright holder:
- © 2017 Smith, et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Journal article
Vortioxetine reduces BOLD signal during performance of the N-Back working memory task: a randomised neuroimaging trial in remitted depressed patients and healthy controls
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