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Journal article

Signaling and polarized communication across the T cell immunological synapse

Abstract:

T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during development to respond to changes in peptides displayed by major histocompatibility complex proteins (pMHC) on the surface of antigen-presenting cells (APC). A key characteristic of pMHC for adaptive immunity is the ability to sample internal states of cells and tissues to sensitively detect changes associated with infection, cell derangement, or tissue injury. Physical T cell-APC contact sets up an ax...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Grant:
Principle Research Fellowship grant 100262/Z/12/Z
Publisher:
Annual Reviews Publisher's website
Journal:
Annual Review of Cell and Developmental Biology Journal website
Volume:
32
Issue:
1
Pages:
303-325
Publication date:
2016-08-03
Acceptance date:
2016-05-09
DOI:
EISSN:
1530-8995
ISSN:
1081-0706
Pubs id:
pubs:638774
URN:
uri:e9c26107-8f05-4510-9741-fec7b7243a00
UUID:
uuid:e9c26107-8f05-4510-9741-fec7b7243a00
Local pid:
pubs:638774
Paper number:
1

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