- Abstract:
-
T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during development to respond to changes in peptides displayed by major histocompatibility complex proteins (pMHC) on the surface of antigen-presenting cells (APC). A key characteristic of pMHC for adaptive immunity is the ability to sample internal states of cells and tissues to sensitively detect changes associated with infection, cell derangement, or tissue injury. Physical T cell-APC contact sets up an ax...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1146/annurev-cellbio-100814-125330
-
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- Publisher:
- Annual Reviews Publisher's website
- Journal:
- Annual Review of Cell and Developmental Biology Journal website
- Volume:
- 32
- Issue:
- 1
- Pages:
- 303-325
- Publication date:
- 2016-08-03
- Acceptance date:
- 2016-05-09
- DOI:
- EISSN:
-
1530-8995
- ISSN:
-
1081-0706
- Pubs id:
-
pubs:638774
- URN:
-
uri:e9c26107-8f05-4510-9741-fec7b7243a00
- UUID:
-
uuid:e9c26107-8f05-4510-9741-fec7b7243a00
- Local pid:
- pubs:638774
- Paper number:
- 1
- Language:
- English
- Keywords:
- Copyright holder:
- Annual Reviews
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 by Annual Reviews.
Journal article
Signaling and polarized communication across the T cell immunological synapse
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