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Journal article

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.

Abstract:

The human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor populations - the lymphoid-primed multi-potential progenitor (LMPP), granulocyte-macrophage progenitor (GMP) and multi-lymphoid progenitor (MLP) - were functionally and transcriptionally distinct and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41590-017-0001-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Oxford college:
St Peter's College
Role:
Author
ORCID:
0000-0001-6192-9145
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-7299-2860
More from this funder
Name:
National Instiutes of Health
Grant:
U01HL099999
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Name:
Wellcome Trust
Grant:
090532/Z/09/Z
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Name:
Bloodwise
Grant:
12019
More from this funder
Name:
Cancer Research UK
Grant:
C5255/A20758
More from this funder
Name:
Medical Research Council
Grant:
MR/M00919X/1
Publisher:
Nature Publishing Group
Journal:
Nature Immunology More from this journal
Volume:
19
Pages:
85–97
Publication date:
2017-11-21
Acceptance date:
2017-10-03
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pmid:
29167569
Language:
English
Keywords:
Pubs id:
pubs:797373
UUID:
uuid:e98946bc-6687-40e7-8360-be6887d1c5a5
Local pid:
pubs:797373
Source identifiers:
797373
Deposit date:
2017-12-21

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