Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.

Journal article

The human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor populations - the lymphoid-primed multi-potential progenitor (LMPP), granulocyte-macrophage progenitor (GMP) and multi-lymphoid progenitor (MLP) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present. Though most progenitors had uni-lineage myeloid or lymphoid potential, bi- and rarer multi-lineage progenitors occurred in LMPP, GMP and MLP. This, coupled with single cell expression analyses, suggested a continuum of progenitors execute lymphoid and myeloid differentiation rather than only uni-lineage progenitors being present downstream of stem cells.

Authors: Karamitros, D; Stoilova, B; Aboukhalil, Z; Hamey, F; Reinisch, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Publishing Group
• Journal: Nature Immunology
• Volume: 19
• Pages: 85–97
• Publication date: 2017-11-21
• Acceptance date: 2017-10-03
• DOI: 10.1038/s41590-017-0001-2
• EISSN: 1529-2916
• ISSN: 1529-2908
• Pmid: 29167569
• Language: English
• Keywords: Journal Article