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Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.

Abstract:

The human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor populations - the lymphoid-primed multi-potential progenitor (LMPP), granulocyte-macrophage progenitor (GMP) and multi-lymphoid progenitor (MLP) - were functionally and transcriptionally distinct and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41590-017-0001-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Oxford college:
St Peters College
ORCID:
0000-0001-6192-9145
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
More by this author
ORCID:
0000-0001-7299-2860
Reinisch, A More by this author
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National Institute for Health Research More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
19
Pages:
85–97
Publication date:
2017-11-21
Acceptance date:
2017-10-03
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:797373
URN:
uri:e98946bc-6687-40e7-8360-be6887d1c5a5
UUID:
uuid:e98946bc-6687-40e7-8360-be6887d1c5a5
Local pid:
pubs:797373
Language:
English
Keywords:

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