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Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release

Abstract:

Pramipexole (PPX) is a high-affinity D2-like dopamine receptor agonist, used in the treatment of Parkinson's disease (PD) and restless leg syndrome. Recent evidence indicates that PPX increases the risk of problem gambling and impulse-control disorders in vulnerable patients. Although the molecular bases of these complications remain unclear, several authors have theorized that PPX may increase risk propensity by activating presynaptic dopamine receptors in the mesolimbic system, resulting in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
ORCID:
0000-0001-9305-1621
Strathman, HJ More by this author
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University of Kansas Strategic Initiatives More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuropharmacology Journal website
Volume:
114
Pages:
77-87
Publication date:
2016-11-23
Acceptance date:
2016-11-21
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Pubs id:
pubs:713563
URN:
uri:e91a8fd9-e421-4901-aec3-dd22af97e718
UUID:
uuid:e91a8fd9-e421-4901-aec3-dd22af97e718
Local pid:
pubs:713563

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