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Chloroquine-primaquine versus chloroquine alone to treat Vivax malaria in Afghanistan: An open randomized superiority trial.

Abstract:

Background

Afghanistan’s national guidelines recommend primaquine for radical treatment of P. vivax malaria but this is rarely implemented because of concerns over potential hemolysis in patients who have G6PD deficiency.

Methods

Between August 2009 and February 2014, we conducted an open-label, randomized controlled trial of chloroquine (CQ) alone versus chloroquine plus primaquine (0.25mg base/kg/day for 14 days)(CQ+PQ) in patients aged > 6 months with micr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.4269/ajtmh.17-0290

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Jeeyapant, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
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Wellcome Trust More from this funder
Publisher:
American Journal of Tropical Medicine and Hygiene Publisher's website
Journal:
American Journal of Tropical Medicine and Hygiene Journal website
Publication date:
2017-12-05
Acceptance date:
2017-08-04
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
Pubs id:
pubs:746809
URN:
uri:e904c2ce-e17f-4abe-b3f0-7ccc1698ea25
UUID:
uuid:e904c2ce-e17f-4abe-b3f0-7ccc1698ea25
Local pid:
pubs:746809
Language:
English
Keywords:

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