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CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype

Abstract:

Gut-associated lymphoid tissue (GALT) is a key location for the HIV reservoir. The observation that B-cell–T-cell doublets are enriched for CD32a (a low-affinity IgG receptor) in peripheral blood raises interesting questions, especially as these cells have been associated with HIV DNA in some studies. We sought to determine if similar doublets were present in GALT, the significance of these doublets, and their implications for the HIV reservoir. Given the importance of GALT as a reservoir for...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41385-019-0180-2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Springer Nature
Journal:
Mucosal Immunology More from this journal
Volume:
12
Issue:
5
Pages:
1212–1219
Publication date:
2019-06-25
Acceptance date:
2019-05-28
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
Language:
English
Pubs id:
pubs:1023568
UUID:
uuid:e9000c40-fc84-40ea-968d-951170bbf731
Local pid:
pubs:1023568
Source identifiers:
1023568
Deposit date:
2019-06-29

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