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TGFB1/INHBA homodimer/nodal-SMAD2/3 signaling network: a pivotal molecular target in PDAC treatment

Abstract:

Pancreatic cancer remains a grueling disease that is projected to become the second-deadliest cancer in the next decade. Standard treatment of pancreatic cancer is chemotherapy, which mainly targets the differentiated population of tumor cells; however, it paradoxically sets the roots of tumor relapse by the selective enrichment of intrinsically chemoresistant pancreatic cancer stem cells that are equipped with an indefinite capacity for self-renewal and differentiation, resulting in tumor re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ymthe.2021.01.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
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Name:
Cancer Research UK
Grant:
25064
Publisher:
Cell Press
Journal:
Molecular Therapy More from this journal
Volume:
29
Issue:
3
Pages:
920-936,
Publication date:
2021-01-08
Acceptance date:
2020-12-14
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Language:
English
Keywords:
Pubs id:
1157495
Local pid:
pubs:1157495
Deposit date:
2021-01-20

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