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Incorporating oxygenation levels in analytical DNA–damage models — quantifying the oxygen fixation mechanism

Abstract:
Purpose: To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA–damage resulting from ionising radiation at variable oxygenation levels.
Methods: Oxygen fixation is treated as a statistical process in a simplified model of complex and simple damage. We show that a linear transformation of ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0002-6894-7829
Publisher:
IOP Publishing
Journal:
Physics in Medicine & Biology More from this journal
Volume:
66
Issue:
14
Article number:
145005
Publication date:
2021-07-09
Acceptance date:
2021-06-15
DOI:
EISSN:
1361-6560
ISSN:
0031-9155
Language:
English
Keywords:
Pubs id:
1182304
Local pid:
pubs:1182304
Deposit date:
2021-06-16

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