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Probing intercell variability using bulk measurements

Abstract:

The measurement of noise is critical when assessing the design and function of synthetic biological systems. Cell-to-cell variability can be quantified experimentally using single-cell measurement techniques such as flow cytometry and fluorescent microscopy. However, these approaches are costly and impractical for high-throughput parallelized experiments, which are frequently conducted using plate-reader devices. In this paper we describe reporter systems that allow estimation of the cell-to-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acssynbio.8b00014

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Worcester College
ORCID:
0000-0002-3565-8967
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Synthetic Biology Journal website
Volume:
7
Issue:
6
Pages:
1528-1537
Publication date:
2018-05-25
Acceptance date:
2018-05-25
DOI:
EISSN:
2161-5063
Pubs id:
pubs:854283
URN:
uri:e8d5f79e-233d-41ec-8263-465aa6d7a081
UUID:
uuid:e8d5f79e-233d-41ec-8263-465aa6d7a081
Local pid:
pubs:854283
Language:
English

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