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MacroD1 is a promiscuous ADP-ribosyl hydrolase localized to mitochondria

Abstract:

MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Dysregulation of MacroD1 expression has been shown to be associated with the pathogenesis of several forms of cancer. To date, the physiological functions and sub-cellular localization of MacroD1 are unclear. Previous studies have described nuclear and cytosolic functions of MacroD1. However, in this study we show that endogenous MacroD1 protein is highly enrich...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Croatian Science Foundation
Grant:
IP–2016–06–4242
More from this funder
Name:
Cancer Research UK
Grant:
C35050/A22284
More from this funder
Name:
Wellcome Trust
Grant:
101794
Publisher:
Frontiers Media
Journal:
Frontiers in Microbiology More from this journal
Volume:
9
Article number:
20
Publication date:
2018-01-23
Acceptance date:
2018-01-05
DOI:
EISSN:
1664-302X
ISSN:
1664-302X
Pmid:
29410655
Language:
English
Keywords:
Pubs id:
pubs:822151
UUID:
uuid:e8d3768f-994c-40c4-9b8c-e4c9268a5041
Local pid:
pubs:822151
Source identifiers:
822151
Deposit date:
2018-03-12

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