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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

Abstract:

T-cell acute lymphoblastic leukaemia (T-ALL) is a blood malignancy afflicting mainly children and adolescents. T-ALL patients present at diagnosis with increased white cell counts and hepatosplenomegaly, and are at an increased risk of central nervous system (CNS) relapse. For that reason, T-ALL patients usually receive cranial irradiation in addition to intensified intrathecal chemotherapy. The marked increase in survival is thought to be worth the considerable side-effects associated with t...

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Publication status:
Published

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Publisher copy:
10.1038/nature08020

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Journal:
Nature More from this journal
Volume:
459
Issue:
7249
Pages:
1000-1004
Publication date:
2009-06-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
pubs:4564
UUID:
uuid:e8cebbe2-fd70-4d17-9190-f6201fdf3973
Local pid:
pubs:4564
Source identifiers:
4564
Deposit date:
2014-07-10

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