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A review of the human Sigma-1 Receptor structure

Abstract:

The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an exce...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/978-3-319-50174-1_3

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Johns College
Role:
Author
ORCID:
0000-0002-8204-7608
Publisher:
Springer Verlag Publisher's website
Volume:
964
Pages:
15-29
Series:
Advances in Experimental Medicine and Biology
Host title:
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Publication date:
2017-03-18
Acceptance date:
2016-05-01
DOI:
EISBN:
978-3-319-50174-1
ISSN:
0065-2598
Pubs id:
pubs:686926
URN:
uri:e8c97507-8d82-4e5d-b80a-5476f2ea6a38
UUID:
uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a38
Local pid:
pubs:686926
ISBN:
978-3-319-50172-7

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