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A review of the human Sigma-1 Receptor structure

Abstract:

The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an exce...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/978-3-319-50174-1_3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-8204-7608
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Name:
Medical Research Council
Grant:
MR/K018590/1
Publisher:
Springer Verlag
Host title:
Advances in experimental medicine and biology
Series:
Advances in Experimental Medicine and Biology
Volume:
964
Pages:
15-29
Publication date:
2017-03-18
Acceptance date:
2016-05-01
DOI:
ISSN:
0065-2598
Pmid:
28315262
ISBN:
9783319501727
Language:
English
Keywords:
Pubs id:
pubs:686926
UUID:
uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a38
Local pid:
pubs:686926
Source identifiers:
686926
Deposit date:
2018-10-18

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