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Membranes as messengers in T cell adhesion signaling.

Abstract:

Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function-associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery ...

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Publisher copy:
10.1038/ni1057

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Nature immunology
Volume:
5
Issue:
4
Pages:
363-372
Publication date:
2004-04-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:e8bf606f-99c8-4fba-b51e-adde4fafd64a
Source identifiers:
482634
Local pid:
pubs:482634

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