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In vivo grafting of large engineered heart tissue patches for cardiac repair

Abstract:

Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordingly, an upscaled EHT patch (2.5 cm × 1.5 cm × 1.5 mm) consisting of up to 20 million human induced pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) embedded in a fibrin-based hydrogel was developed. A rabbit myocardial infarction ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.144068

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Role:
Author
ORCID:
0000-0003-1054-6456
Publisher:
American Society for Clinical Investigation
Journal:
JCI Insight More from this journal
Volume:
6
Issue:
15
Article number:
e144068
Place of publication:
United States
Publication date:
2021-08-09
Acceptance date:
2021-06-23
DOI:
EISSN:
2379-3708
Pmid:
34369384
Language:
English
Keywords:
Pubs id:
1190264
Local pid:
pubs:1190264
Deposit date:
2022-01-14

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