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Journal article

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Abstract:

Despite impressive clinical success, cancer immunotherapy based on immune checkpoint blockade remains ineffective in many patients due to tumoral resistance. Here we use the autochthonous TiRP melanoma model, which recapitulates the tumoral resistance signature observed in human melanomas. TiRP tumors resist immunotherapy based on checkpoint blockade, cancer vaccines or adoptive T-cell therapy. TiRP tumors recruit and activate tumorspecific CD8+ T cells, but these cells then undergo apopto...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-00784-1

Authors


Powis de Tenbossche, CG More by this author
van Baren, N More by this author
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Ludwig Cancer Research More from this funder
Walloon Excellence in Life Sciences and Biotechnology More from this funder
FNRSTélévie More from this funder
Foundation Against Cancer More from this funder
de Duve Institute and Université catholique de Louvain More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
1404
Publication date:
2017-11-10
Acceptance date:
2017-07-27
DOI:
ISSN:
2041-1723
Pubs id:
pubs:745913
URN:
uri:e8869efa-4cf8-47ff-9e70-9eea520563ed
UUID:
uuid:e8869efa-4cf8-47ff-9e70-9eea520563ed
Local pid:
pubs:745913

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