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Electrohydrodynamic fabrication of core–shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment

Abstract:

Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control the distribution of CDDP within the particles, and high encapsulation efficiency (>70%) of the drug was achieved. NPs were pr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.2147/ijn.s134833

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Publisher:
Dove Press Publisher's website
Journal:
International Journal of Nanomedicine Journal website
Volume:
12
Pages:
3913-3926
Publication date:
2017-05-23
Acceptance date:
2017-04-06
DOI:
EISSN:
1178-2013
ISSN:
1176-9114
Pubs id:
pubs:700610
URN:
uri:e866fd33-d4bc-4f2e-b82d-da0453ca3f9b
UUID:
uuid:e866fd33-d4bc-4f2e-b82d-da0453ca3f9b
Local pid:
pubs:700610

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