- Abstract:
-
Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control the distribution of CDDP within the particles, and high encapsulation efficiency (>70%) of the drug was achieved. NPs were pr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.2MB)
-
- Publisher copy:
- 10.2147/ijn.s134833
-
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- Grant:
- EP/L026287/1 and EP/ L025825/1
- Publisher:
- Dove Press Publisher's website
- Journal:
- International Journal of Nanomedicine Journal website
- Volume:
- 12
- Pages:
- 3913-3926
- Publication date:
- 2017-05-23
- Acceptance date:
- 2017-04-06
- DOI:
- EISSN:
-
1178-2013
- ISSN:
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1176-9114
- Pubs id:
-
pubs:700610
- URN:
-
uri:e866fd33-d4bc-4f2e-b82d-da0453ca3f9b
- UUID:
-
uuid:e866fd33-d4bc-4f2e-b82d-da0453ca3f9b
- Local pid:
- pubs:700610
- Language:
- English
- Keywords:
- Copyright holder:
- Reardon et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Reardon et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Electrohydrodynamic fabrication of core–shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment
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+ Engineering and Physical Sciences Research Council
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