Journal article
Electrohydrodynamic fabrication of core–shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment
- Abstract:
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Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control the distribution of CDDP within the particles, and high encapsulation efficiency (>70%) of the drug was achieved. NPs were pr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.2MB)
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- Publisher copy:
- 10.2147/ijn.s134833
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Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Grant:
EP/L026287/1
EP/
L025825/1
Bibliographic Details
- Publisher:
- Dove Press Publisher's website
- Journal:
- International Journal of Nanomedicine Journal website
- Volume:
- 12
- Pages:
- 3913-3926
- Publication date:
- 2017-05-23
- Acceptance date:
- 2017-04-06
- DOI:
- EISSN:
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1178-2013
- ISSN:
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1176-9114
- Pmid:
-
28579777
- Source identifiers:
-
700610
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:700610
- UUID:
-
uuid:e866fd33-d4bc-4f2e-b82d-da0453ca3f9b
- Local pid:
- pubs:700610
- Deposit date:
- 2017-10-11
Terms of use
- Copyright holder:
- Reardon et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Reardon et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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