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Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex

Abstract:

Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or by dynamic (time-varying) activity across a neural population. Here, we compare these hypotheses across four regions of prefrontal cortex (PFC) in an oculomotor-delayed-response task, where an intervening cue indicated the reward available for a correct saccade. WM representations were strongest in ventrolateral PFC neurons with higher intrinsic temporal stability (time-constant...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-05873-3

Authors


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ORCID:
0000-0001-9275-2725
Towers, JP More by this author
Wallis, JD More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
ORCID:
0000-0002-8393-8533
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ORCID:
0000-0002-5696-7507
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Funding agency for:
Hunt, LT
Middlesex Hospital Medical School General Charitable Trust. More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
3498
Publication date:
2018-08-29
Acceptance date:
2018-07-31
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:935880
URN:
uri:e81c9bd2-611a-4a3d-bf37-87a7a57dc6bf
UUID:
uuid:e81c9bd2-611a-4a3d-bf37-87a7a57dc6bf
Local pid:
pubs:935880
Language:
English
Keywords:

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