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Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA.

Abstract:

Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this pathogen. We have previously observed a reserpine-sensitive fluoroquinolone (FQ) efflux phenotype in this species. Here, SatAB and SmrA, two pumps belonging to the ATP binding cassette (ABC) and the major facilitator superfamily (MFS), respectively, have been analyzed in the fluoroquinolone-resistant clinical isolate BB1013. Genes enco...

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Publisher copy:
10.1128/aac.00498-11

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
55
Issue:
12
Pages:
5850-5860
Publication date:
2011-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:e8143145-876d-4301-b5ea-f957ac1a561c
Source identifiers:
386889
Local pid:
pubs:386889

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