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Cell-derived viral genes evolve under stronger purifying selection in Rhadinoviruses

Abstract:

Like many other large dsDNA viruses, herpesviruses are known to capture host genes to evade host defenses. Little is known about the detailed natural history of such genes, nor do we fully understand their evolutionary dynamics. A major obstacle is that they are often highly divergent, maintaining very low sequence similarity to host homologs. Here, we use the herpesvirus genus Rhadinovirus as a model system to develop an analytical approach that combines complementary evolutionary and bioinf...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1128/jvi.00359-18

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
ORCID:
0000-0002-5776-0057
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
St Hildas College
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
92
Issue:
19
Pages:
Article: e00359-18
Publication date:
2018-07-11
Acceptance date:
2018-07-11
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:869320
URN:
uri:e8110b5e-faeb-4bbf-b739-b7f7c2141a7f
UUID:
uuid:e8110b5e-faeb-4bbf-b739-b7f7c2141a7f
Local pid:
pubs:869320
Language:
English
Keywords:

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