Thesis
Mapping networks of alpha-Synuclein proteostasis in cellular models of Parkinson's disease pathology
- Abstract:
-
Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which there is no disease-modifying therapy. Pathologically, the neuronal loss correlates with abnormal accumulation, aggregation and toxic gain of function of the small pre-synaptic protein alpha-Synuclein (aSyn). Whether neurons degrade aggregated aSyn or, only its soluble monomers, remains elusive. This thesis combines hypothesis-driven and unbiased genetic screens to identify pathways that specifically regu...
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Funding
IMPRIND
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2020-10-07
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Terms of use
- Copyright holder:
- Rahel Lewin
- Copyright date:
- 2020
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