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Thesis

Mapping networks of alpha-Synuclein proteostasis in cellular models of Parkinson's disease pathology

Abstract:

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which there is no disease-modifying therapy. Pathologically, the neuronal loss correlates with abnormal accumulation, aggregation and toxic gain of function of the small pre-synaptic protein alpha-Synuclein (aSyn). Whether neurons degrade aggregated aSyn or, only its soluble monomers, remains elusive. This thesis combines hypothesis-driven and unbiased genetic screens to identify pathways that specifically regu...

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Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Linacre College

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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