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Lifespan of human lymphocyte subsets defined by CD45 isoforms.

Abstract:

The lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms of CD45 corresponds with their ability to respond to recall antigens, we have investigated the lifespan of both CD45R0 (the subs...

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Publisher copy:
10.1038/360264a0

Authors


Michie, CA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Nature
Volume:
360
Issue:
6401
Pages:
264-265
Publication date:
1992-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:e80a0cb4-b10f-4b2e-a68a-5a0a4794f94d
Source identifiers:
32494
Local pid:
pubs:32494

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