Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

Journal article

Acetonides are the only protecting groups used in the syntheses of isoDAB from d-ribose and of isoLAB from d-tagatose. isoDAB is a potent and highly specific competitive α-glucosidase inhibitor (for rice α-glucosidase, Ki = 4 μM for isoDAB compared to K i 14 μM for DAB). isoDAB is not an - whereas DAB is a potent - inhibitor of glycogen phosphorylase. This is the first example of any potent inhibition of glycosidases by a carbon-branched iminosugar pyrrolidine. Although isoLAB shows no inhibi...

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Authors: Best, D; Jenkinson, S; Saville, A; Alonzi, D; Wormald, M

• Publication status: Published
• Journal: TETRAHEDRON LETTERS
• Volume: 51
• Issue: 32
• Pages: 4170-4174
• Publication date: 2010-08-11
• DOI: 10.1016/j.tetlet.2010.05.131
• ISSN: 0040-4039
• Language: English