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Journal article

α-synuclein genetic variability: A biomarker for dementia in Parkinson disease

Abstract:

Objective
The relationship between Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB) has long been debated. Although PD is primarily considered a motor disorder, cognitive impairment is often present at diagnosis, and only ∼20% of patients remain cognitively intact in the long term. Alpha-synuclein (SNCA) was first implicated in the pathogenesis of the disease when point mutations and locus multiplications were identified in familial parkinsonism with de...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ana.24664

Authors


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Michael J. Fox Foundation for Parkinson’s Research More from this funder
Canada Excellence Research Chairs Program More from this funder
Cundill Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
Annals of Neurology Journal website
Volume:
79
Issue:
6
Pages:
991-999
Publication date:
2016-05-05
Acceptance date:
2016-04-06
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Source identifiers:
622415
Pubs id:
pubs:622415
UUID:
uuid:e7f1fb76-b9f8-48ed-a616-0bcfb3d6cbc9
Local pid:
pubs:622415
Deposit date:
2016-06-24

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