- Abstract:
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Objective
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The relationship between Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB) has long been debated. Although PD is primarily considered a motor disorder, cognitive impairment is often present at diagnosis, and only ∼20% of patients remain cognitively intact in the long term. Alpha-synuclein (SNCA) was first implicated in the pathogenesis of the disease when point mutations and locus multiplications were identified in familial parkinsonism with de... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
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(pdf, 566.6KB)
-
- Publisher copy:
- 10.1002/ana.24664
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- Publisher:
- Wiley Publisher's website
- Journal:
- Annals of Neurology Journal website
- Volume:
- 79
- Issue:
- 6
- Pages:
- 991-999
- Publication date:
- 2016-05-05
- DOI:
- EISSN:
-
1531-8249
- ISSN:
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0364-5134
- URN:
-
uuid:e7f1fb76-b9f8-48ed-a616-0bcfb3d6cbc9
- Source identifiers:
-
622415
- Local pid:
- pubs:622415
- Paper number:
- 6
- Copyright holder:
- American Neurological Association
- Copyright date:
- 2016
- Notes:
- © 2016 American Neurological Association. This is the accepted manuscript version of the article. The final version is available online from Wiley at: [10.1002/ana.24664]
Journal article
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease
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Authors
Funding
Michael J. Fox Foundation for Parkinson’s Research
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Canada Excellence Research Chairs Program
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Cundill Foundation
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