Journal article
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease
- Abstract:
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Objective
Expand abstract
The relationship between Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB) has long been debated. Although PD is primarily considered a motor disorder, cognitive impairment is often present at diagnosis, and only ∼20% of patients remain cognitively intact in the long term. Alpha-synuclein (SNCA) was first implicated in the pathogenesis of the disease when point mutations and locus multiplications were identified in familial parkinsonism with de...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 566.6KB)
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- Publisher copy:
- 10.1002/ana.24664
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Authors
Funding
Michael J. Fox Foundation for Parkinson’s Research
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Canada Excellence Research Chairs Program
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Cundill Foundation
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Annals of Neurology Journal website
- Volume:
- 79
- Issue:
- 6
- Pages:
- 991-999
- Publication date:
- 2016-05-05
- Acceptance date:
- 2016-04-06
- DOI:
- EISSN:
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1531-8249
- ISSN:
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0364-5134
- Source identifiers:
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622415
Item Description
- Pubs id:
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pubs:622415
- UUID:
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uuid:e7f1fb76-b9f8-48ed-a616-0bcfb3d6cbc9
- Local pid:
- pubs:622415
- Deposit date:
- 2016-06-24
Terms of use
- Copyright holder:
- American Neurological Association
- Copyright date:
- 2016
- Notes:
- © 2016 American Neurological Association. This is the accepted manuscript version of the article. The final version is available online from Wiley at: [10.1002/ana.24664]
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