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Journal article

DNA-damage response control of E2F7 and E2F8.

Abstract:

Here, we report that the two recently identified E2F subunits, E2F7 and E2F8, are induced in cells treated with DNA-damaging agents where they have an important role in dictating the outcome of the DNA-damage response. The DNA-damage-dependent induction coincides with the binding of E2F7 and E2F8 to the promoters of certain E2F-responsive genes, most notably that of the E2F1 gene, in which E2F7 and E2F8 coexist in a DNA-binding complex. As a consequence, E2F7 and E2F8 repress E2F target genes...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7401158

Authors


Zalmas, LP More by this author
Graham, AL More by this author
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Journal:
EMBO reports
Volume:
9
Issue:
3
Pages:
252-259
Publication date:
2008-03-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:e7ea7cbd-2b6e-4c04-bdd6-63225d559525
Source identifiers:
269961
Local pid:
pubs:269961

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