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Basic statistical analysis in genetic case-control studies.

Abstract:

This protocol describes how to perform basic statistical analysis in a population-based genetic association case-control study. The steps described involve the (i) appropriate selection of measures of association and relevance of disease models; (ii) appropriate selection of tests of association; (iii) visualization and interpretation of results; (iv) consideration of appropriate methods to control for multiple testing; and (v) replication strategies. Assuming no previous experience with soft...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2010.182

Authors


Clarke, GM More by this author
Anderson, CA More by this author
Pettersson, FH More by this author
Cardon, LR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Nature protocols
Volume:
6
Issue:
2
Pages:
121-133
Publication date:
2011-02-05
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
URN:
uuid:e7e3a6b1-7baa-4280-955c-7d128f207aad
Source identifiers:
118024
Local pid:
pubs:118024

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