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Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success.

Abstract:

Drug therapies against persistent human infections such as hepatitis C virus, hepatitis B virus, and HIV fail to consistently eradicate the infection from the host. Hence, recent emphasis has shifted to the study of antiviral therapy aimed at boosting specific immune responses. It was argued that structured therapy interruptions were required to achieve this, because such regimes have shown promising results in early HIV infection. Using mathematical models, we show that, contrary to this not...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0337483100

Authors


Komarova, NL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
4
Pages:
1855-1860
Publication date:
2003-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e7cafe60-3ac9-4367-86a4-11efd64eb23d
Source identifiers:
27860
Local pid:
pubs:27860

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