Journal article icon

Journal article

A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.

Abstract:

The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms for 11 MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2,162 case-controls d...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00439-008-0597-2

Authors


Journal:
Human genetics More from this journal
Volume:
125
Issue:
1
Pages:
105-109
Publication date:
2009-02-01
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
Language:
English
Keywords:
Pubs id:
pubs:34493
UUID:
uuid:e7b8fa21-b1cf-4a03-a392-6d41c9eccaee
Local pid:
pubs:34493
Source identifiers:
34493
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP