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Sensitive detection of chromosomal segments of distinct ancestry in admixed populations.

Abstract:

Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease mapping to learning about history. Most methods require the use of unlinked markers; but, using all markers from genome-wide scanning arrays, it should in principle be possible to infer the ancestry of even very small segments with exquisite accuracy. We describe a method, HAPMIX, which employs an explicit population genetic model to perform such local ancestry inference based o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1000519

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Publisher:
Public Library of Science
Journal:
PLoS genetics More from this journal
Volume:
5
Issue:
6
Article number:
e1000519
Publication date:
2009-06-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:e7b872bd-63c1-4c0d-81db-d83e8b98eb2d
Local pid:
pubs:103198
Source identifiers:
103198
Deposit date:
2012-12-19

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