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Thesis

Regulation of de novo lipogenesis and fatty acid desaturation in human adipocytes

Abstract:

De novo lipogenesis (DNL) in the human adipocyte is not fully understood. While some believe this to be an insignificant pathway, others have argued that adipose tissue may even be the main site of DNL. The enzyme stearoyl-CoA desaturase (SCD) plays a key role in the synthesis of monounsaturated fatty acids and its activity may be co-ordinately regulated with DNL. The recently-described Scdl knockout mouse model fuelled interest in this enzyme as a possible target for the...

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Peer review status:
Peer reviewed

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Department:
University of Oxford
Role:
Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:e7b59f77-fcf6-4927-afbe-cf730a1d428f
Local pid:
polonsky:13:1
Source identifiers:
601870829
Deposit date:
2017-10-05

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