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Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial.

Abstract:

BACKGROUND: Lithium has neuroprotective effects in cell and animal models of amyotrophic lateral sclerosis (ALS), and a small pilot study in patients with ALS showed a significant effect of lithium on survival. We aimed to assess whether lithium improves survival in patients with ALS. METHODS: The lithium carbonate in amyotrophic lateral sclerosis (LiCALS) trial is a randomised, double-blind, placebo-controlled trial of oral lithium taken daily for 18 months in patients with ALS. Patients age...

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Publication status:
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Authors


Morrison, KE More by this author
Dhariwal, S More by this author
Hornabrook, R More by this author
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Journal:
The Lancet. Neurology
Volume:
12
Issue:
4
Pages:
339-345
Publication date:
2013-04-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:e7ab6c01-35ae-4949-8bcd-c42252528705
Source identifiers:
394305
Local pid:
pubs:394305

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