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Prolonged osteogenesis from human mesenchymal stem cells implanted in immunodeficient mice by using coralline hydroxyapatite incorporating rhBMP2 microspheres.

Abstract:

The local environment plays an important role in osteogenic tissue regeneration. Our previous studies have shown that xenogenic transplantation of human mesenchymal stem cells (hMSCs) alone into immunodeficient mice did not result in long-term bone formation. This study investigates whether bone formation can be prolonged by incorporating human mesenchymal stem cells in mineralized scaffolds together with controlled delivery of a growth factor, BMP2. A composite of coralline hydroxyapatite (C...

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Publication status:
Published

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Publisher copy:
10.1002/jbm.a.32453

Authors


Czernuszka, J More by this author
McKenna, CE More by this author
Ebetino, FH More by this author
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Journal:
Journal of biomedical materials research. Part A
Volume:
92
Issue:
4
Pages:
1256-1264
Publication date:
2010-03-05
DOI:
EISSN:
1552-4965
ISSN:
1549-3296
URN:
uuid:e7a75e1d-21b7-4f0b-abfa-08034ecb8fb4
Source identifiers:
108722
Local pid:
pubs:108722

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