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Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers.

Abstract:

In 2008, dihydroartemisinin (DHA)-piperaquine (PPQ) became the first-line treatment for uncomplicated Plasmodium falciparum malaria in western Cambodia. Recent reports of increased treatment failure rates after DHA-PPQ therapy in this region suggest that parasite resistance to DHA, PPQ, or both is now adversely affecting treatment. While artemisinin (ART) resistance is established in western Cambodia, there is no evidence of PPQ resistance. To monitor for resistance to PPQ and other antimalar...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00687-13

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
57
Issue:
11
Pages:
5277-5283
Publication date:
2013-11-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804

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