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Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes.

Abstract:

Previous work has shown that interleukin 1 (IL-1) increases the activity of acid extruders in articular chondrocytes, while the H+-adenosine triphosphatase (ATPase) inhibitor bafilomycin can prevent aggrecanase-mediated cartilage degradation. The H+ transport induced by IL-1 may therefore be required for proteinase activity. In the present study, the effects of hexosamines and fish oils on H+-ATPase activity have been characterised for isolated bovine articular chondrocytes. Cells isolated in...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-007-0425-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology More from this journal
Volume:
456
Issue:
3
Pages:
501-506
Publication date:
2008-06-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768

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