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Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation.

Abstract:

Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underly...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02298-13

Authors


Huiskonen, JT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Journal:
Journal of virology
Volume:
87
Issue:
23
Pages:
13070-13075
Publication date:
2013-12-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:e7996f12-6b94-4a7a-a823-cabac1b59a5f
Source identifiers:
429422
Local pid:
pubs:429422

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