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Journal article

Pressure-induced unfolding of the molten globule of all-Ala alpha-lactalbumin.

Abstract:

Pressure-induced unfolding of a molten globule (MG) was studied in a residue-specific manner with (1)H-(15)N two-dimensional NMR spectroscopy using a variant of human alpha-lactalbumin (alpha-LA), in which all eight cysteines had been replaced with alanines (all-Ala alpha-LA). The NMR spectrum underwent a series of changes from 30 to 2000 bar at 20 degrees C and from -18 degrees C to 36 degrees C at 2000 bar, showing a highly heterogeneous unfolding pattern according to the secondary structur...

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Publication status:
Published

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Publisher copy:
10.1110/ps.0221303

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Protein science : a publication of the Protein Society More from this journal
Volume:
12
Issue:
1
Pages:
66-72
Publication date:
2003-01-01
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
Language:
English
Keywords:
Pubs id:
pubs:100423
UUID:
uuid:e78e96e2-d61e-45fb-8a22-76511de9e4b2
Local pid:
pubs:100423
Source identifiers:
100423
Deposit date:
2012-12-19

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